Limba
Romanian
Romanian
English|
GSK2606414 is an orally available, potent, and selective PERKinhibitor with IC50of 0.4 nM, displaying at least 100-fold selectivity over the other EIF2AKs assayed. GSK2606414 impairs GANT-61 induced autophagyin NB cells with MYCN amplification. GSK2606414 exacerbates ER stress-induced apoptosisin HCT116 cells while reduces the apoptosisin SIL1 KD HeLa cells.
| Price | 1.658,00 RON (preturile sunt fara TVA) |
|---|---|
| Description |
GSK2606414 is an orally available, potent, and selective PERKinhibitor with IC50of 0.4 nM, displaying at least 100-fold selectivity over the other EIF2AKs assayed. GSK2606414 impairs GANT-61 induced autophagyin NB cells with MYCN amplification. GSK2606414 exacerbates ER stress-induced apoptosisin HCT116 cells while reduces the apoptosisin SIL1 KD HeLa cells. |
