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GSK2606414, 50mg

GSK2606414, 50mg

GSK2606414, 10mM/1mL

GSK2606414, 10mM/1mL

GSK2606414, 1g

12.909,12 RON
SKU
SKM_S7307_1g
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GSK2606414 is an orally available, potent, and selective PERKinhibitor with IC50of 0.4 nM, displaying at least 100-fold selectivity over the other EIF2AKs assayed. GSK2606414 impairs GANT-61 induced autophagyin NB cells with MYCN amplification. GSK2606414 exacerbates ER stress-induced apoptosisin HCT116 cells while reduces the apoptosisin SIL1 KD HeLa cells.

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Description

GSK2606414 is an orally available, potent, and selective PERKinhibitor with IC50of 0.4 nM, displaying at least 100-fold selectivity over the other EIF2AKs assayed. GSK2606414 impairs GANT-61 induced autophagyin NB cells with MYCN amplification. GSK2606414 exacerbates ER stress-induced apoptosisin HCT116 cells while reduces the apoptosisin SIL1 KD HeLa cells.
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