Selumetinib (AZD6244), 10mM/1mL

Selumetinib (AZD6244), 10mM/1mL

Dactolisib (BEZ235), 1g

Dactolisib (BEZ235), 1g

Dactolisib (BEZ235), 50mg

1.180,48 RON
SKU
SKM_S1009_50mg

Dactolisib (BEZ235, NVP-BEZ235) is a dual ATP-competitive PI3Kand mTORinhibitor for p110α/γ/δ/β and mTOR(p70S6K) with IC50 of 4 nM /5 nM /7 nM /75 nM /6 nM in cell-free assays, respectively. Inhibits ATR with IC50 of 21 nM in 3T3TopBP1-ER cell. Dactolisib induces autophagyand suppresses HIV-1replication. Phase 2.

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Description

Dactolisib (BEZ235, NVP-BEZ235) is a dual ATP-competitive PI3Kand mTORinhibitor for p110α/γ/δ/β and mTOR(p70S6K) with IC50 of 4 nM /5 nM /7 nM /75 nM /6 nM in cell-free assays, respectively. Inhibits ATR with IC50 of 21 nM in 3T3TopBP1-ER cell. Dactolisib induces autophagyand suppresses HIV-1replication. Phase 2.