Tozasertib (VX-680), 250mg

Tozasertib (VX-680) is a pan-Aurora inhibitor, mostly against Aurora Awith Kiappof 0.6 nM in a cell-free assay, less potent towards Aurora B/Aurora C and 100-fold more selective for Aurora A than 55 other kinases. The only exceptions are Fms-related tyrosine kinase-3 (FLT-3)and BCR-ABL tyrosine kinase, which are inhibited by the Tozasertib with both Ki of 30 nM. Tozasertib induces apoptosisand autophagy. Phase 2.