Limba
Romanian
Romanian
English|
Tozasertib (VX-680), 1g
12.261,76 RON
SKU
SKM_S1048_1g
Tozasertib (VX-680) is a pan-Aurora inhibitor, mostly against Aurora Awith Kiappof 0.6 nM in a cell-free assay, less potent towards Aurora B/Aurora C and 100-fold more selective for Aurora A than 55 other kinases. The only exceptions are Fms-related tyrosine kinase-3 (FLT-3)and BCR-ABL tyrosine kinase, which are inhibited by the Tozasertib with both Ki of 30 nM. Tozasertib induces apoptosisand autophagy. Phase 2.
| Price | 10.304,00 RON (preturile sunt fara TVA) |
|---|---|
| Description |
Tozasertib (VX-680) is a pan-Aurora inhibitor, mostly against Aurora Awith Kiappof 0.6 nM in a cell-free assay, less potent towards Aurora B/Aurora C and 100-fold more selective for Aurora A than 55 other kinases. The only exceptions are Fms-related tyrosine kinase-3 (FLT-3)and BCR-ABL tyrosine kinase, which are inhibited by the Tozasertib with both Ki of 30 nM. Tozasertib induces apoptosisand autophagy. Phase 2. |
