Niraparib (MK-4827), 10mM/1mL

Niraparib (MK-4827), 10mM/1mL

PHA-767491 HCl, 50mg

PHA-767491 HCl, 50mg

PHA-767491 HCl, 10mg

1.180,48 RON
SKU
SKM_S2742_10mg

PHA-767491 (CAY10572, NMS 1116354) HCl is a potent ATP-competitive dual Cdc7/CDK9inhibitor with IC50of 10 nM and 34 nM in cell-free assays, respectively.It displays ~20-fold selectivity against CDK1/2 and GSK3-β, 50-fold selectivity against MK2 and CDK5, 100-fold selectivity against PLK1 and CHK2.

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Description

PHA-767491 (CAY10572, NMS 1116354) HCl is a potent ATP-competitive dual Cdc7/CDK9inhibitor with IC50of 10 nM and 34 nM in cell-free assays, respectively.It displays ~20-fold selectivity against CDK1/2 and GSK3-β, 50-fold selectivity against MK2 and CDK5, 100-fold selectivity against PLK1 and CHK2.