NK-252, 25mg

NK-252, 25mg

LDC195943 (IMT1), 25mg

LDC195943 (IMT1), 25mg

LDC195943 (IMT1), 5mg

1.821,89 RON
SKU
SKM_E0443_5mg

LDC195943 (IMT1) is a specific and noncompetitive inhibitor of human mitochondrial RNA polymerase(POLRMT). IMT1 causes a conformational change of POLRMT, which blocks substrate binding and transcription in a dose-dependent way in vitro. IMT1 reduces deoxynucleoside triphosphate levels and citric acid cycle intermediates, resulting in a marked depletion of cellular amino acid levels. IMT1 has the potential for mitochondrial transcription disorders related diseases.

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Description

LDC195943 (IMT1) is a specific and noncompetitive inhibitor of human mitochondrial RNA polymerase(POLRMT). IMT1 causes a conformational change of POLRMT, which blocks substrate binding and transcription in a dose-dependent way in vitro. IMT1 reduces deoxynucleoside triphosphate levels and citric acid cycle intermediates, resulting in a marked depletion of cellular amino acid levels. IMT1 has the potential for mitochondrial transcription disorders related diseases.