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Romanian
Romanian
English|
LDC195943 (IMT1) is a specific and noncompetitive inhibitor of human mitochondrial RNA polymerase(POLRMT). IMT1 causes a conformational change of POLRMT, which blocks substrate binding and transcription in a dose-dependent way in vitro. IMT1 reduces deoxynucleoside triphosphate levels and citric acid cycle intermediates, resulting in a marked depletion of cellular amino acid levels. IMT1 has the potential for mitochondrial transcription disorders related diseases.
| Price | 4.193,00 RON (preturile sunt fara TVA) |
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| Description |
LDC195943 (IMT1) is a specific and noncompetitive inhibitor of human mitochondrial RNA polymerase(POLRMT). IMT1 causes a conformational change of POLRMT, which blocks substrate binding and transcription in a dose-dependent way in vitro. IMT1 reduces deoxynucleoside triphosphate levels and citric acid cycle intermediates, resulting in a marked depletion of cellular amino acid levels. IMT1 has the potential for mitochondrial transcription disorders related diseases. |
