(E/Z)-BCI, 25mg

(E/Z)-BCI, 25mg

N-Succinimidyl-S-acetylthioacetate (SATA), 25mg

N-Succinimidyl-S-acetylthioacetate (SATA), 25mg

(E/Z)-BCI, 10mM/1mL

2.143,19 RON
SKU
SKM_S0056_10mM/1mL

(E/Z)-BCI (BCI, NSC 150117) is an inhibitor of dual specific phosphatase 1/6 (DUSP1/DUSP6)and mitogen-activated protein kinasewith EC50 of 13.3 μM and 8.0 μM for DUSP6 and DUSP1 in cells, respectively. (E)-BCI induces apoptosisvia generation of reactive oxygen species (ROS)and activation of intrinsic mitochondrial pathway in H1299 lung cancer cells.

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Description

(E/Z)-BCI (BCI, NSC 150117) is an inhibitor of dual specific phosphatase 1/6 (DUSP1/DUSP6)and mitogen-activated protein kinasewith EC50 of 13.3 μM and 8.0 μM for DUSP6 and DUSP1 in cells, respectively. (E)-BCI induces apoptosisvia generation of reactive oxygen species (ROS)and activation of intrinsic mitochondrial pathway in H1299 lung cancer cells.