Limba
Romanian
Romanian
English|
VU661013 is a novel, potent, selective MCL1inhibitor with Ki of 97 ± 30 pM of human MCL-1 in a TR-FRET assay. However, VU661013 does not significantly inhibit BCL-xL or BCL-2 with Ki > 40 μM or = 0.73 μM. VU661013 de-stabilizes BIM/MCL-1 association, leads to apoptosisin AML.
| Price | 3.280,00 RON (preturile sunt fara TVA) |
|---|---|
| Description |
VU661013 is a novel, potent, selective MCL1inhibitor with Ki of 97 ± 30 pM of human MCL-1 in a TR-FRET assay. However, VU661013 does not significantly inhibit BCL-xL or BCL-2 with Ki > 40 μM or = 0.73 μM. VU661013 de-stabilizes BIM/MCL-1 association, leads to apoptosisin AML. |
