Vistusertib (AZD2014), 25mg

Vistusertib (AZD2014) is a novel mTORinhibitor with IC50 of 2.8 nM in a cell-free assay; highly selective against multiple PI3Kisoforms (α/β/γ/δ). AZD2014 showed no or weak binding to the majority of kinases when tested at 1 μM. AZD2014 induces proliferation suppression, apoptosis, cell cycle arrest, and autophagyin HCC cells with antitumor activity.