Limba
Romanian
Romanian
English|
Vandetanib is a potent inhibitor of VEGFR2with IC50 of 40 nM in a cell-free assay. It also inhibits VEGFR3and EGFRwith IC50 of 110 nM and 500 nM, respectively. Not sensitive to PDGFRβ, Flt1, Tie-2 and FGFR1 with IC50 of 1.1-3.6 μM. No activity against MEK, CDK2, c-Kit, erbB2, FAK, PDK1, Akt and IGF-1R with IC50 above 10 μM. Vandetanib (ZD6474) increases apoptosisand induces autophagyby increasing the level of reactive oxygen species (ROS).
| Price | 992,00 RON (preturile sunt fara TVA) |
|---|---|
| Description |
Vandetanib is a potent inhibitor of VEGFR2with IC50 of 40 nM in a cell-free assay. It also inhibits VEGFR3and EGFRwith IC50 of 110 nM and 500 nM, respectively. Not sensitive to PDGFRβ, Flt1, Tie-2 and FGFR1 with IC50 of 1.1-3.6 μM. No activity against MEK, CDK2, c-Kit, erbB2, FAK, PDK1, Akt and IGF-1R with IC50 above 10 μM. Vandetanib (ZD6474) increases apoptosisand induces autophagyby increasing the level of reactive oxygen species (ROS). |
