Tefinostat(CHR-2845), 5mg

Tefinostat(CHR-2845), 5mg

Tefinostat(CHR-2845), 100mg

Tefinostat(CHR-2845), 100mg

Tefinostat(CHR-2845), 25mg

5.232,43 RON
SKU
SKM_E1554_25mg

Tefinostat(CHR-2845) is a monocyte/macrophage-targeted inhibitor of pan-histone deacetylase(HDAC). Tefinostat undergoes cleavage mediated by the intracellular esterase human carboxylesterase-1 (hCE-1) to yield the active acid CHR-2847. In vitro studies reveal a specific heightened sensitivity of monocytoid leukemias to tefinostat.

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Description

Tefinostat(CHR-2845) is a monocyte/macrophage-targeted inhibitor of pan-histone deacetylase(HDAC). Tefinostat undergoes cleavage mediated by the intracellular esterase human carboxylesterase-1 (hCE-1) to yield the active acid CHR-2847. In vitro studies reveal a specific heightened sensitivity of monocytoid leukemias to tefinostat.