SP600125, 10mg

SP600125, 10mg

SP600125, 1g

SP600125, 1g

SP600125, 50mg

1.821,89 RON
SKU
SKM_S1460_50mg

SP600125 (Nsc75890) is a broad-spectrum JNKinhibitor for JNK1, JNK2 and JNK3 with IC50of 40 nM, 40 nM and 90 nM in cell-free assays, respectively; 10-fold greater selectivity against MKK4, 25-fold greater selectivity against MKK3, MKK6, PKB, and PKCα, and 100-fold selectivity against ERK2, p38, Chk1, EGFR etc. SP600125 is also a broad‐spectrum inhibitor of serine/threonine kinasesincluding Aurora kinase A,FLT3and TRKAwith of IC50 of 60 nM, 90 nM and 70 nM. SP600125 inhibits autophagyand activates apoptosis.

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Description

SP600125 (Nsc75890) is a broad-spectrum JNKinhibitor for JNK1, JNK2 and JNK3 with IC50of 40 nM, 40 nM and 90 nM in cell-free assays, respectively; 10-fold greater selectivity against MKK4, 25-fold greater selectivity against MKK3, MKK6, PKB, and PKCα, and 100-fold selectivity against ERK2, p38, Chk1, EGFR etc. SP600125 is also a broad‐spectrum inhibitor of serine/threonine kinasesincluding Aurora kinase A,FLT3and TRKAwith of IC50 of 60 nM, 90 nM and 70 nM. SP600125 inhibits autophagyand activates apoptosis.