Sorafenib tosylate, 1g

Sorafenib tosylate is a multikinase inhibitor of Raf-1and B-Rafwith IC50of 6 nM and 22 nM in cell-free assays, respectively. Sorafenib Tosylate inhibits VEGFR-2, VEGFR-3, PDGFR-β, Flt-3and c-KITwith IC50 of 90 nM, 20 nM, 57 nM, 59 nM and 68 nM, respectively. Sorafenib Tosylate induces autophagyand apoptosisand activates ferroptosiswith anti-tumor activity.