PFM01, 25mg

PFM01, 25mg

SIS3, 25mg

SIS3, 25mg

SIS3, 5mg

1.769,53 RON
SKU
SKM_S3552_5mg

SIS3 is a cell-permeable inhibitor of Smad3 that selectively inhibits TGF-β1-dependent Smad3phosphorylation and Smad3-mediated cellular signaling. SIS3 reduces TGF-β1-induced type 1 procollagenexpression and myofibroblastdifferentiation in normal dermal fibroblasts as well as scleroderma fibroblasts.

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Description

SIS3 is a cell-permeable inhibitor of Smad3 that selectively inhibits TGF-β1-dependent Smad3phosphorylation and Smad3-mediated cellular signaling. SIS3 reduces TGF-β1-induced type 1 procollagenexpression and myofibroblastdifferentiation in normal dermal fibroblasts as well as scleroderma fibroblasts.