Shikonin, a potent and specific Pyruvate kinase M2 (PKM2)inhibitor, is a major component of zicao (purple gromwell, the dried root of Lithospermum erythrorhizon), a Chinese herbal medicine with various biological activities. It is also an inhibitor of TMEM16A chloride channelactivity using cell-based fluorescent-quenching assay. Shikonin exerts an anti-inflammatory effect by inhibiting tumor necrosis factor-α (TNF-α)and prevents activation of nuclear factor-κB (NF-κB)pathway via proteasomeinhibition.
Price | 1.262,00 RON (preturile sunt fara TVA) |
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Description |
Shikonin, a potent and specific Pyruvate kinase M2 (PKM2)inhibitor, is a major component of zicao (purple gromwell, the dried root of Lithospermum erythrorhizon), a Chinese herbal medicine with various biological activities. It is also an inhibitor of TMEM16A chloride channelactivity using cell-based fluorescent-quenching assay. Shikonin exerts an anti-inflammatory effect by inhibiting tumor necrosis factor-α (TNF-α)and prevents activation of nuclear factor-κB (NF-κB)pathway via proteasomeinhibition. |