Sepantronium Bromide (YM155), 1g

Sepantronium Bromide (YM155), 1g

3-Aminobenzamide, 5mg

3-Aminobenzamide, 5mg

Sepantronium Bromide (YM155), 10mM/1mL

1.501,78 RON
SKU
SKM_S1130_10mM/1mL

Sepantronium Bromide(YM155) is a potent survivinsuppressant by inhibiting Survivin promoter activity with IC50of 0.54 nM in HeLa-SURP-luc and CHO-SV40-luc cells; does not significantly inhibit SV40 promoter activity, but is observed to slightly inhibit the interaction of Survivin with XIAP. YM155 down-regulates survivinand XIAP, modulates autophagyand induces autophagy-dependent DNA damage in breast cancer cells. Phase 2.

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Description

Sepantronium Bromide(YM155) is a potent survivinsuppressant by inhibiting Survivin promoter activity with IC50of 0.54 nM in HeLa-SURP-luc and CHO-SV40-luc cells; does not significantly inhibit SV40 promoter activity, but is observed to slightly inhibit the interaction of Survivin with XIAP. YM155 down-regulates survivinand XIAP, modulates autophagyand induces autophagy-dependent DNA damage in breast cancer cells. Phase 2.