Resibufogenin (Bufogenin, Recibufogenin), a component of huachansu with anticancer effect, triggers necroptosis through upregulating receptor-interacting protein kinase 3 (RIP3)and phosphorylating mixed lineage kinase domain-like proteinat Ser358. Resibufogenin exerts cytotoxic effect by inducing reactive oxygen species (ROS)accumulation. Resibufogenin induces apoptosisand caspase-3and caspase-8activity. Resibufogenin increases Bax/Bcl-2expression, and suppresses cyclin D1, cyclin E, PI3K, p-AKT, p-GSK3βand β-cateninprotein expression.
Price | 992,00 RON (preturile sunt fara TVA) |
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Description |
Resibufogenin (Bufogenin, Recibufogenin), a component of huachansu with anticancer effect, triggers necroptosis through upregulating receptor-interacting protein kinase 3 (RIP3)and phosphorylating mixed lineage kinase domain-like proteinat Ser358. Resibufogenin exerts cytotoxic effect by inducing reactive oxygen species (ROS)accumulation. Resibufogenin induces apoptosisand caspase-3and caspase-8activity. Resibufogenin increases Bax/Bcl-2expression, and suppresses cyclin D1, cyclin E, PI3K, p-AKT, p-GSK3βand β-cateninprotein expression. |