Resibufogenin, 1mg

Resibufogenin (Bufogenin, Recibufogenin), a component of huachansu with anticancer effect, triggers necroptosis through upregulating receptor-interacting protein kinase 3 (RIP3)and phosphorylating mixed lineage kinase domain-like proteinat Ser358. Resibufogenin exerts cytotoxic effect by inducing reactive oxygen species (ROS)accumulation. Resibufogenin induces apoptosisand caspase-3and caspase-8activity. Resibufogenin increases Bax/Bcl-2expression, and suppresses cyclin D1, cyclin E, PI3K, p-AKT, p-GSK3βand β-cateninprotein expression.