Fostamatinib (R788), 10mM/1mL

Fostamatinib (R788), 10mM/1mL

Rabusertib (LY2603618), 50mg

Rabusertib (LY2603618), 50mg

Rabusertib (LY2603618), 5mg

1.331,61 RON
SKU
SKM_S2626_5mg

Rabusertib (LY2603618, IC-83) is a highly selective Chk1inhibitor with potential anti-tumor activity in a cell-free assay. IC50=7 nM, showing approximately 100-fold more potent against Chk1 than against any of the other protein kinases evaluated. Rabusertib (LY2603618) induces cell cycle arrest, DNA damage response and autophagyin cancer cells. Rabusertib (LY2603618) induces bak-dependent apoptosisin AML cell lines.

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Description

Rabusertib (LY2603618, IC-83) is a highly selective Chk1inhibitor with potential anti-tumor activity in a cell-free assay. IC50=7 nM, showing approximately 100-fold more potent against Chk1 than against any of the other protein kinases evaluated. Rabusertib (LY2603618) induces cell cycle arrest, DNA damage response and autophagyin cancer cells. Rabusertib (LY2603618) induces bak-dependent apoptosisin AML cell lines.