PF-4708671, 1g

PF-4708671, 1g

Bazedoxifene acetate, 10mg

Bazedoxifene acetate, 10mg

PF-4708671, 10mM/1mL

1.462,51 RON
SKU
SKM_S2163_10mM/1mL

PF-4708671 is a cell-permeable inhibitor of p70 ribosomal S6 kinase(S6K1 isoform) with Ki/IC50of 20 nM/160 nM in cell-free assays, 400-fold greater selectivity for S6K1 than S6K2, and 4- and >20-fold selectivity for S6K1 than MSK1 and RSK1/2, respectively. PF-4708671 induces autophagy. First S6K1-specific inhibitor to be reported.

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Description

PF-4708671 is a cell-permeable inhibitor of p70 ribosomal S6 kinase(S6K1 isoform) with Ki/IC50of 20 nM/160 nM in cell-free assays, 400-fold greater selectivity for S6K1 than S6K2, and 4- and >20-fold selectivity for S6K1 than MSK1 and RSK1/2, respectively. PF-4708671 induces autophagy. First S6K1-specific inhibitor to be reported.