PCNA-I1, 5mg

PCNA-I1, 5mg

PCNA-I1, 10mM/1mL

PCNA-I1, 10mM/1mL

PCNA-I1, 25mg

9.683,03 RON
SKU
SKM_S4476_25mg

PCNA-I1 is a selective inhibitor of proliferating cell nuclear antigen (PCNA, a potential anticancer target). PCNA-I1 selectively binds to PCNA trimers with Kd of ~0.2 to 0.4 μM. PCNA-I1 inhibits the growth of tumor cells of various tissue types with IC50 of ~0.2 μM. PCNA-I1 induces DNA damageand apoptosisin both LNCaP and PC-3 cells. PCNA-I1 also induces autophagyin PC-3 cells.

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Description

PCNA-I1 is a selective inhibitor of proliferating cell nuclear antigen (PCNA, a potential anticancer target). PCNA-I1 selectively binds to PCNA trimers with Kd of ~0.2 to 0.4 μM. PCNA-I1 inhibits the growth of tumor cells of various tissue types with IC50 of ~0.2 μM. PCNA-I1 induces DNA damageand apoptosisin both LNCaP and PC-3 cells. PCNA-I1 also induces autophagyin PC-3 cells.