o-Phenanthroline (1,10-Phenanthroline, phen), a hypoxia-mimicking agent, is a non-specific matrix metalloproteinase (MMP)inhibitor with IC50 of 110.5μM for Collagenase. O-phenanthroline reduces the expression of MMP3and MMP13mRNA levels during chondrogenic differentiation of human chondrocytes (hChs), as well as after TNFα/IL-1β exposure in an explant model. o-Phenanthroline is also a metalchelator which prevents the induction of chromosomal aberrations in streptozotocin-treated cells and forms a red chelate with Fe2+that absorbs maximally at 510 nm.
Price | 992,00 RON (preturile sunt fara TVA) |
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Description |
o-Phenanthroline (1,10-Phenanthroline, phen), a hypoxia-mimicking agent, is a non-specific matrix metalloproteinase (MMP)inhibitor with IC50 of 110.5μM for Collagenase. O-phenanthroline reduces the expression of MMP3and MMP13mRNA levels during chondrogenic differentiation of human chondrocytes (hChs), as well as after TNFα/IL-1β exposure in an explant model. o-Phenanthroline is also a metalchelator which prevents the induction of chromosomal aberrations in streptozotocin-treated cells and forms a red chelate with Fe2+that absorbs maximally at 510 nm. |