Narciclasine, 5mg

Narciclasine (Lycoricidinol), an isocarbostyril alkaloid narciclasine, targets STAT3via distinct mechanisms in tamoxifen-resistant breast cancer cells. Narciclasine suppresses phosphorylation, activation, dimerization, and nuclear translocation of STAT3 by directly binding with the STAT3 SH2 domain and leads STAT3 degradation. Narciclasine is a plant growthmodulator. Narciclasine modulates the Rho/Rho kinase/LIM kinase/cofilinsignaling pathway, greatly increasing GTPase RhoA activity as well as inducing actin stress fiber formation in a RhoA-dependent manner.