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Eltanexor (KPT-8602), 10mM/1mL

Eltanexor (KPT-8602), 10mM/1mL

Mivebresib (ABBV-075), 25mg

Mivebresib (ABBV-075), 25mg

Mivebresib (ABBV-075), 5mg

1.180,48 RON
SKU
SKM_S8400_5mg
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Mivebresib (ABBV-075) is a novel BET family bromodomaininhibitor. It binds bromodomains of BRD2/4/T with similar affinities (Ki of 1-2.2 nM) and highly selective for 18 bromodomain proteins tested (Kd > 1 μM; more than 600-fold selectivity vs. BRD4), but exhibits roughly 10-fold weaker potency towards BRD3 (Ki of 12.2 nM) and has moderate activity towards CREBBP (Kd = 87 μM; 54-fold selectivity vs. BRD4). Mivebresib(ABBV-075) efficiently triggers apoptosisin various tumor cell.

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Price 992,00 RON (preturile sunt fara TVA)
Description

Mivebresib (ABBV-075) is a novel BET family bromodomaininhibitor. It binds bromodomains of BRD2/4/T with similar affinities (Ki of 1-2.2 nM) and highly selective for 18 bromodomain proteins tested (Kd > 1 μM; more than 600-fold selectivity vs. BRD4), but exhibits roughly 10-fold weaker potency towards BRD3 (Ki of 12.2 nM) and has moderate activity towards CREBBP (Kd = 87 μM; 54-fold selectivity vs. BRD4). Mivebresib(ABBV-075) efficiently triggers apoptosisin various tumor cell.
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