MAZ51 is a potent and selective inhibitor of vascular endothelial growth factor receptor (VEGFR)-3 (Flt-4) tyrosine kinase. MAZ51 induces cell rounding and G2/M cell cycle arrest in glioma cells through phosphorylation of Akt/GSK3βand activation of RhoA. MAZ51 inhibits the proliferation and induces the apoptosisof a variety of non-VEGFR-3-expressing tumor cell lines.
Price | 992,00 RON (preturile sunt fara TVA) |
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Description |
MAZ51 is a potent and selective inhibitor of vascular endothelial growth factor receptor (VEGFR)-3 (Flt-4) tyrosine kinase. MAZ51 induces cell rounding and G2/M cell cycle arrest in glioma cells through phosphorylation of Akt/GSK3βand activation of RhoA. MAZ51 inhibits the proliferation and induces the apoptosisof a variety of non-VEGFR-3-expressing tumor cell lines. |