Limba
Romanian
Romanian
English|
M2912 (MSC2504877) is a very potent TNKS1/TNKS2inhibitor (IC50=0.6 nM for TNKS1) with exquisite selectivity over other PARPfamily enzymes and favorable compound properties. This inhibitor potently modulates the Wnt/β-cateninpathway by elevating the levels of axin2 (EC50=17 nM) and tankyrasein DLD1 cells in a dose-dependent manner resulting in reduced cellular Wntreporter activity.
| Price | 3.748,00 RON (preturile sunt fara TVA) |
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| Description |
M2912 (MSC2504877) is a very potent TNKS1/TNKS2inhibitor (IC50=0.6 nM for TNKS1) with exquisite selectivity over other PARPfamily enzymes and favorable compound properties. This inhibitor potently modulates the Wnt/β-cateninpathway by elevating the levels of axin2 (EC50=17 nM) and tankyrasein DLD1 cells in a dose-dependent manner resulting in reduced cellular Wntreporter activity. |
