Limba
Romanian
Romanian
English|
LY294002 (SF 1101, NSC 697286) is the first synthetic molecule known to inhibit PI3Kα/δ/βwith IC50of 0.5 μM/0.57 μM/0.97 μM, respectively; more stable in solution than Wortmannin, and also blocks autophagosome formation. It not only binds to class I PI3Ks and other PI3K-related kinases, but also to novel targets seemingly unrelated to the PI3K family. LY294002 also inhibits CK2with IC50 of 98 nM. LY294002 is a non-specific DNA-PKcsinhibitor and activates autophagyand apoptosis.
| Price | 992,00 RON (preturile sunt fara TVA) |
|---|---|
| Description |
LY294002 (SF 1101, NSC 697286) is the first synthetic molecule known to inhibit PI3Kα/δ/βwith IC50of 0.5 μM/0.57 μM/0.97 μM, respectively; more stable in solution than Wortmannin, and also blocks autophagosome formation. It not only binds to class I PI3Ks and other PI3K-related kinases, but also to novel targets seemingly unrelated to the PI3K family. LY294002 also inhibits CK2with IC50 of 98 nM. LY294002 is a non-specific DNA-PKcsinhibitor and activates autophagyand apoptosis. |
