Limba
Romanian
Romanian
English|
LY2811376 is the first orally available non-peptidic β-secretase(BACE1)inhibitor with IC50of 239 nM-249 nM, that act to decrease Aβ secretion with EC50of 300 nM, demonstrated to have 10-fold selectivity towards BACE1 over BACE2, and more than 50-fold inhibition over other aspartic proteases including cathepsin D, pepsin, or renin. Phase 1.
| Price | 1.119,00 RON (preturile sunt fara TVA) |
|---|---|
| Description |
LY2811376 is the first orally available non-peptidic β-secretase(BACE1)inhibitor with IC50of 239 nM-249 nM, that act to decrease Aβ secretion with EC50of 300 nM, demonstrated to have 10-fold selectivity towards BACE1 over BACE2, and more than 50-fold inhibition over other aspartic proteases including cathepsin D, pepsin, or renin. Phase 1. |
