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English|
Lenalidomide is a TNF-αsecretion inhibitor with IC50of 13 nM in PBMCs. Lenalidomide (CC-5013) is a ligand of ubiquitin E3 ligase cereblon (CRBN), and it causes selective ubiquitination and degradation of two lymphoid transcription factors, IKZF1 and IKZF3, by the CRBN-CRL4 ubiquitin ligase. Lenalidomide promotes cleaved caspase-3expression and inhibit VEGFexpression and induces apoptosis.
| Price | 3.819,00 RON (preturile sunt fara TVA) |
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| Description |
Lenalidomide is a TNF-αsecretion inhibitor with IC50of 13 nM in PBMCs. Lenalidomide (CC-5013) is a ligand of ubiquitin E3 ligase cereblon (CRBN), and it causes selective ubiquitination and degradation of two lymphoid transcription factors, IKZF1 and IKZF3, by the CRBN-CRL4 ubiquitin ligase. Lenalidomide promotes cleaved caspase-3expression and inhibit VEGFexpression and induces apoptosis. |
