Limba
Romanian
Romanian
English|
LC-2 is a first PROTAC capable of degrading endogenous KRASG12Cwith DC50s between 0.25 μM and 0.76 μM. LC-2 covalently binds KRASG12C with a MRTX849 warhead and recruits the E3 ligase VHL, inducing rapid and sustained KRASG12C degradation leading to suppression of MAPK signaling.
| Price | 5.442,00 RON (preturile sunt fara TVA) |
|---|---|
| Description |
LC-2 is a first PROTAC capable of degrading endogenous KRASG12Cwith DC50s between 0.25 μM and 0.76 μM. LC-2 covalently binds KRASG12C with a MRTX849 warhead and recruits the E3 ligase VHL, inducing rapid and sustained KRASG12C degradation leading to suppression of MAPK signaling. |
