KN-62, 100mg

KN-62, 100mg

KN-62, 10mM/1mL

KN-62, 10mM/1mL

KN-62, 1g

25.901,54 RON
SKU
SKM_S7422_1g

KN-62 is a potent and specific inhibitor of Ca2+/calmodulin-dependent protein kinase II (CaMKII)with Kiof 0.9 μM; also a non-competitive antagonist of the purinergic receptor P2RX7(IC50 = 15 nM). It is selective for CaMKII relative to PKA, PKC and MLCK, but inhibits CaMKI and CaMKIV equally well, The Ki value of KN-62 for CaMK V is 0.8 μM.

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Description

KN-62 is a potent and specific inhibitor of Ca2+/calmodulin-dependent protein kinase II (CaMKII)with Kiof 0.9 μM; also a non-competitive antagonist of the purinergic receptor P2RX7(IC50 = 15 nM). It is selective for CaMKII relative to PKA, PKC and MLCK, but inhibits CaMKI and CaMKIV equally well, The Ki value of KN-62 for CaMK V is 0.8 μM.