Indisulam, 1g

Indisulam (E7070), a sulfonamide anticancer agent, is a potent carbonic anhydrase (CA)inhibitor that inhibits cytosolic isozymes Iand II, and transmembrane, tumor-associated isozyme IX. Indisulam suppresses the expression of cyclin Eand phosphorylation of CDK2, both of which are essential for the G1 to S transition.