BDTX-1535, 25mg

BDTX-1535, 25mg

I-138, 25mg

I-138, 25mg

I-138, 5mg

3.314,15 RON
SKU
SKM_E1479_5mg

I-138 is an orally active, potent reversible inhibitor of USP1-UAF1with IC50 0f 4.1 nM. I-138 is structurally related to ML323 and induces the monoubiquitination of FANCD2 and PCNA in MDA-MB-436 cells and increases PCNA and FANCD2 monoubiquitination in HAP-1 USP1 WT cells.

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Description

I-138 is an orally active, potent reversible inhibitor of USP1-UAF1with IC50 0f 4.1 nM. I-138 is structurally related to ML323 and induces the monoubiquitination of FANCD2 and PCNA in MDA-MB-436 cells and increases PCNA and FANCD2 monoubiquitination in HAP-1 USP1 WT cells.