BRD3308, 10mM/1mL

BRD3308, 10mM/1mL

HLM006474, 25mg

HLM006474, 25mg

HLM006474, 5mg

1.180,48 RON
SKU
SKM_S8963_5mg

HLM006474 is a small molecule pan-E2Finhibitor that inhibits DNA binding to E2F4 with IC50 of 29.8 µM in A375 cells. HLM006474 induces a reduction in cell proliferation and an increase in apoptosis. The CDK/Rb/E2F pathway is commonly disrupted in lung cancer, and HLM006474 is shown to have efficacy in lung cancer.

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Description

HLM006474 is a small molecule pan-E2Finhibitor that inhibits DNA binding to E2F4 with IC50 of 29.8 µM in A375 cells. HLM006474 induces a reduction in cell proliferation and an increase in apoptosis. The CDK/Rb/E2F pathway is commonly disrupted in lung cancer, and HLM006474 is shown to have efficacy in lung cancer.