Hispidulin, 1mg

Hispidulin (Dinatin), an active natrual ingredient in a number of traditional Chinese medicinal herbs, exhibits inhibitory activity against the oncogenic protein kinase Pim-1with IC50 of 2.71 μM. Hispidulin induces apoptosisthrough mitochondrial dysfunctionand inhibition of P13k/Aktsignalling pathway in HepG2 cancer cells. Hispidulin exerts anti-osteoporotic and bone resorption attenuating effects via activating the AMPKsignaling pathway.