Limba
Romanian
Romanian
English|
GSK690693 is a pan-Akt inhibitor targeting Akt1/2/3with IC50of 2 nM/13 nM/9 nM in cell-free assays, also sensitive to the AGC kinase family: PKA, PrkX and PKC isozymes. GSK690693 also potently inhibits AMPKand DAPK3from the CAMK family with IC50 of 50 nM and 81 nM, respectively. GSK690693 affects Unc-51-like autophagy activating kinase 1 (ULK1)activity, robustly inhibits STING-dependent IRF3activation. Phase 1.
| Price | 27.062,00 RON (preturile sunt fara TVA) |
|---|---|
| Description |
GSK690693 is a pan-Akt inhibitor targeting Akt1/2/3with IC50of 2 nM/13 nM/9 nM in cell-free assays, also sensitive to the AGC kinase family: PKA, PrkX and PKC isozymes. GSK690693 also potently inhibits AMPKand DAPK3from the CAMK family with IC50 of 50 nM and 81 nM, respectively. GSK690693 affects Unc-51-like autophagy activating kinase 1 (ULK1)activity, robustly inhibits STING-dependent IRF3activation. Phase 1. |
