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Enitociclib (BAY 1251152), 2mg
1.180,48 RON
SKU
SKM_S8730_2mg
Enitociclib (BAY 1251152) is a potent PTEFb/CDK9inhibitor with an IC50 value of 3 nM for CDK9 and an at least 50-fold selectivity against other CDKs in enzymatic assays. BAY1251152 binds to and blocks the phosphorylation and kinase activity of CDK9, thereby preventing PTEFb-mediated activation of RNA Pol II and leading to the inhibition of gene transcription of various anti-apoptotic proteins.
| Price | 992,00 RON (preturile sunt fara TVA) |
|---|---|
| Description |
Enitociclib (BAY 1251152) is a potent PTEFb/CDK9inhibitor with an IC50 value of 3 nM for CDK9 and an at least 50-fold selectivity against other CDKs in enzymatic assays. BAY1251152 binds to and blocks the phosphorylation and kinase activity of CDK9, thereby preventing PTEFb-mediated activation of RNA Pol II and leading to the inhibition of gene transcription of various anti-apoptotic proteins. |
