Lesinurad sodium, 25mg

Lesinurad sodium, 25mg

Crizotinib hydrochloride, 25mg

Crizotinib hydrochloride, 25mg

Crizotinib hydrochloride, 5mg

1.180,48 RON
SKU
SKM_S5190_5mg

Crizotinib (PF-02341066) hydrochloride (Xalkori) inhibits tyrosine phosphorylation of c-Metand nucleophosmin (NPM)-anaplastic lymphoma kinase (ALK)with IC50 of of 11 nM and 24 nM in cell-based assays, respectively. Crizotinib hydrochloride is also a potent ROS1inhibitor with Ki less than 0.025 nM. Crizotinib induces autophagythrough inhibition of the STAT3 pathway in multiple lung cancer cell lines.

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Description

Crizotinib (PF-02341066) hydrochloride (Xalkori) inhibits tyrosine phosphorylation of c-Metand nucleophosmin (NPM)-anaplastic lymphoma kinase (ALK)with IC50 of of 11 nM and 24 nM in cell-based assays, respectively. Crizotinib hydrochloride is also a potent ROS1inhibitor with Ki less than 0.025 nM. Crizotinib induces autophagythrough inhibition of the STAT3 pathway in multiple lung cancer cell lines.