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English|
CCT128930 is a potent, ATP-competitive and selective inhibitor of Akt2with IC50of 6 nM in a cell-free assay, 28-fold greater selectivity for Akt2 than the closely related PKA kinase. CCT128930 induces cell cycle arrest, DNA damage, and autophagyindependent of Akt inhibition. High dose of CCT128930 triggers cell apoptosisin HepG2 cells.
| Price | 1.443,00 RON (preturile sunt fara TVA) |
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| Description |
CCT128930 is a potent, ATP-competitive and selective inhibitor of Akt2with IC50of 6 nM in a cell-free assay, 28-fold greater selectivity for Akt2 than the closely related PKA kinase. CCT128930 induces cell cycle arrest, DNA damage, and autophagyindependent of Akt inhibition. High dose of CCT128930 triggers cell apoptosisin HepG2 cells. |
