Anti-Glucagon mouse monoclonal, 1 mL, Species x-Reactivity: human, Applications: IHC

GCG

Cat#: BSH-7443-100 100ul, BSH-7443-1 1ml, BSH-7443-RTU 7ml
Clone: BS71
S/R: human
Application: IHC

The protein encoded by this gene is actually a preproprotein that is cleaved into four distinct mature peptides. One of these, glucagon, is a pancreatic hormone that counteracts the glucose-lowering action of insulin by stimulating glycogenolysis and gluconeogenesis. Glucagon is a ligand for a specific G-protein linked receptor whose signalling pathway controls cell proliferation. Two of the other peptides are secreted from gut endocrine cells and promote nutrient absorption through distinct mechanisms. Finally, the fourth peptide is similar to glicentin, an active enteroglucagon.Tissue specificity: Glucagon is secreted in the A cells of the islets of Langerhans. GLP-1, GLP-2, oxyntomodulin and glicentin are secreted from enteroendocrine cells throughout the gastrointestinal tract. GLP1 and GLP2 are also secreted in selected neurons in the brain.

Glucagon stained tissue sections. Alpha cells of Langerhans islets secrete glucagon, which is detected using Glucagon Optibody (Clone: BS71). Alpha cells are common in the edges of islets (a, b, and c).