Anti-Desmin, mouse monoclonal, 1 ml, Species x-Reactivity: human, Applications: IHC

Desmin

Cat#: BSH-7082-100 100ul, BSH-7082-1 1ml, BSH-7082-RTU 7ml
Clone: BS21
S/R: human, rat
Application: IHC
Tissue control: Appendix, placenta

Desmin (DES), with 470-amino acid protein (about 52kDa), belongs to the intermediate filament family and Desmin is class III intermediate filaments found in muscle cells. Homopolymers of Desmin form a stable intracytoplasmic filamentous network connecting myofibrils to each other and to the plasma membrane. Mutations in Desmin are associated with desmin-related myopathy, a familial cardiac and skeletal myopathy (CSM), and with distal myopathies.Desmin is also expressed in smooth muscle cells of both airways and alveolar ducts and Desmin is a load-bearing protein that stiffens the airways and consequently the lung and modulates airway contractile response.

Desmin stained tissue sections. Desmin Optibody (Clone: BS21) offers similar staining pattern. Also muscular layers of the small arteries are stained (a). Muscles of fetal part of placenta are strongly stained without any background staining (b). Rhabdomyosarcoma was stained strongly with Optibody (c).