Anti-CD38, mouse monoclonal, 1 ml, Species x-Reactivity: human, Applications: IHC

CD38

Cat#: BSH-7347-100 100ul, BSH-7347-1 1ml, BSH-7347-RTU 7ml
Clone: BS3
S/R: human
Application: IHC

CD38 is a type II integral membrane glycoprotein which is present on early B and T cell lineages and activated B and T cells but is absent from most mature resting peripheral lymphocytes. CD38 is also found on thymocytes, pre-B cells, germinal center B cells, mitogen-activated T cells, monocytes and Ig-secreting plasma cells. CD38 acts as a NAD glycohydrolase in T lym- phocytes. On hematopoietic cells CD38 induces activation, proliferation, and differentiation of mature T and B cells and mediates apoptosis of myeloid and lymphoid progenitor cells. In addition to acting as a signaling receptor, CD38 is also an enzyme capable of producing several calcium-mobilizing metabo- lites, including cyclic adenosine diphosphate ribose (cADPR). CD38 also plays a role in maintaining survival of an invariant NK T (iNKT) cell subset that preferentially contributes to the maintenance of immunological tolerance.

CD38 stained tissue sections. Image (a) appendix and (b) tonsil sections have been stained using CD38 optibody (Clone: BS3) with 1:200 dilution. Strong membranous staining observed from scattered B-cells in germinal center and plasma cells. Antibody offers excellent signal to noise ratio.