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Cabozantinib (XL184), 50mg
3.255,84 RON
SKU
SKM_S1119_50mg
Cabozantinib (XL184) is a potent VEGFR2inhibitor with IC50of 0.035 nM and also inhibits c-Met, Ret, Kit, Flt-1/3/4, Tie2, and AXL with IC50of 1.3 nM, 4 nM, 4.6 nM, 12 nM/11.3 nM/6 nM, 14.3 nM and 7 nM in cell-free assays, respectively. Cabozantinib induces PUMA-dependent apoptosisin colon cancer cells via AKT/GSK-3β/NF-κB signaling pathway.
| Price | 2.736,00 RON (preturile sunt fara TVA) |
|---|---|
| Description |
Cabozantinib (XL184) is a potent VEGFR2inhibitor with IC50of 0.035 nM and also inhibits c-Met, Ret, Kit, Flt-1/3/4, Tie2, and AXL with IC50of 1.3 nM, 4 nM, 4.6 nM, 12 nM/11.3 nM/6 nM, 14.3 nM and 7 nM in cell-free assays, respectively. Cabozantinib induces PUMA-dependent apoptosisin colon cancer cells via AKT/GSK-3β/NF-κB signaling pathway. |
