S1404S, RNA Cap Struc Analog [m7G(5')ppp(5')G] - 25 A260 units

Cap analogs are used for cotransciptional capping of in vitro transcribed RNA. For most RNAs, elimination of the cap structure causes a loss of stability, especially against exonuclease degradation, and a decrease in the formation of the initiation complex of mRNAs for protein synthesis. Certain prokaryotic mRNAs containing a 5´ terminal cap structure are translated as efficiently as or more efficiently than eukaryotic mRNAs in a eukaryotic cell-free protein synthesizing system. Also a cap requirement has been observed for splicing eukaryotic substrate RNAs.

Sequence
7mG(5´)ppp(5´)G