Limba
Romanian
Romanian
English|
BAY 1125976 is a selective allosteric AKT1/2inhibitor,exhibits high efficacy on AKT signaling-dependent tumor growth in mouse models. BAY1125976 inhibits the activity of AKT1(IC50 = 5.2 nM at 10 µM ATP and 44 nM at 2 mM ATP) and AKT2(IC50 = 18 nM at 10 µM ATP and 36 nM at 2 mM ATP) very potently.Whereas BAY1125976 is almost inactive on AKT3(IC50 = 427 nM at 10 µM ATP).
| Price | 2.884,00 RON (preturile sunt fara TVA) |
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| Description |
BAY 1125976 is a selective allosteric AKT1/2inhibitor,exhibits high efficacy on AKT signaling-dependent tumor growth in mouse models. BAY1125976 inhibits the activity of AKT1(IC50 = 5.2 nM at 10 µM ATP and 44 nM at 2 mM ATP) and AKT2(IC50 = 18 nM at 10 µM ATP and 36 nM at 2 mM ATP) very potently.Whereas BAY1125976 is almost inactive on AKT3(IC50 = 427 nM at 10 µM ATP). |
