AZD5153 6-hydroxy-2-naphthoic acid, 1g

AZD5153 6-hydroxy-2-naphthoic acid, 1g

ONO-7300243, 5mg

ONO-7300243, 5mg

AZD5153 6-hydroxy-2-naphthoic acid, 10mM/1mL

2.221,73 RON
SKU
SKM_S8344_10mM/1mL

AZD5153 6-hydroxy-2-naphthoic acid (HNT salt) is a potent, selective, and orally available BET/BRD4bromodomain inhibitor with pKi of 8.3 for BRD4. AZD5153 inhibits the expression of Nuclear receptor binding SET domain protein 3 (NSD3)target genes. NSD3, via H3K36me2, acts as an epigenetic deregulator to facilitate the expression of oncogenesis-promoting genes.

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Description

AZD5153 6-hydroxy-2-naphthoic acid (HNT salt) is a potent, selective, and orally available BET/BRD4bromodomain inhibitor with pKi of 8.3 for BRD4. AZD5153 inhibits the expression of Nuclear receptor binding SET domain protein 3 (NSD3)target genes. NSD3, via H3K36me2, acts as an epigenetic deregulator to facilitate the expression of oncogenesis-promoting genes.