VU0119498, 5mg

VU0119498, 5mg

Apilimod mesylate, 25mg

Apilimod mesylate, 25mg

Apilimod mesylate, 5mg

1.180,48 RON
SKU
SKM_S0785_5mg

Apilimod mesylate is a potent and orally-available inhibitor of the cytokines interleukin-12 (IL-12)and interleukin-23 (IL-23)with the potential to treat certain autoimmune and inflammatory diseases. Apilimod mesylate (STA-5326 mesylate) inhibits IL-12 with IC50 of 1 nM, 1 nM and 2 nM, in IFN-γ/SAC-stimulated human PBMCs, human monocytes and mouse PBMCs, respectively. Apilimod mesylate (STA-5326 mesylate) is also a cell permeable small molecule that specifically inhibits PIKfyvewith IC50 of 14 nM.

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Description

Apilimod mesylate is a potent and orally-available inhibitor of the cytokines interleukin-12 (IL-12)and interleukin-23 (IL-23)with the potential to treat certain autoimmune and inflammatory diseases. Apilimod mesylate (STA-5326 mesylate) inhibits IL-12 with IC50 of 1 nM, 1 nM and 2 nM, in IFN-γ/SAC-stimulated human PBMCs, human monocytes and mouse PBMCs, respectively. Apilimod mesylate (STA-5326 mesylate) is also a cell permeable small molecule that specifically inhibits PIKfyvewith IC50 of 14 nM.