fexaramine, 25mg

fexaramine, 25mg

Apilimod, 25mg

Apilimod, 25mg

Apilimod, 5mg

1.180,48 RON
SKU
SKM_S6414_5mg

Apilimod is a potent and orally-available inhibitor of the cytokines interleukin-12 (IL-12)and interleukin-23 (IL-23)with the potential to treat certain autoimmune and inflammatory diseases. Apilimod (STA-5326) inhibits IL-12 with IC50 of 1 nM, 1 nM and 2 nM, in IFN-γ/SAC-stimulated human PBMCs, human monocytes and mouse PBMCs, respectively. Apilimod (STA-5326) is also a cell permeable small molecule that specifically inhibits PIKfyvewith IC50 of 14 nM.

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Description

Apilimod is a potent and orally-available inhibitor of the cytokines interleukin-12 (IL-12)and interleukin-23 (IL-23)with the potential to treat certain autoimmune and inflammatory diseases. Apilimod (STA-5326) inhibits IL-12 with IC50 of 1 nM, 1 nM and 2 nM, in IFN-γ/SAC-stimulated human PBMCs, human monocytes and mouse PBMCs, respectively. Apilimod (STA-5326) is also a cell permeable small molecule that specifically inhibits PIKfyvewith IC50 of 14 nM.