Limba
Romanian
Romanian
English|
AMG-9810 is a potent, competitive and selective vanilloid receptor 1 (TRPV1)antagonist and inhibits capsaicin activation with IC50 of 24.5 nM and 85.6 nM for human TRPV1 and rat TRPV1, repectively. AMG-9810 blocks all known modes of TRPV1 activation, including protons-, heat-, and endogenous ligands, such as anandamide, N-arachidonyl dopamine, and oleoyldopamine. AMG-9810 significantly reduces the mRNA expression of TLR2and TLR4. AMG-9810 also promotes mouse skin tumorigenesis mediated through EGFR/Akt/mTORsignaling.
| Price | 992,00 RON (preturile sunt fara TVA) |
|---|---|
| Description |
AMG-9810 is a potent, competitive and selective vanilloid receptor 1 (TRPV1)antagonist and inhibits capsaicin activation with IC50 of 24.5 nM and 85.6 nM for human TRPV1 and rat TRPV1, repectively. AMG-9810 blocks all known modes of TRPV1 activation, including protons-, heat-, and endogenous ligands, such as anandamide, N-arachidonyl dopamine, and oleoyldopamine. AMG-9810 significantly reduces the mRNA expression of TLR2and TLR4. AMG-9810 also promotes mouse skin tumorigenesis mediated through EGFR/Akt/mTORsignaling. |
